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KMID : 1007320070130020096
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Journal of the Korean Society of Menopause
2007 Volume.13 No. 2 p.96 ~ p.105
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The Relationship between Changes in the Production of Osteoprotegerin (OPG), Soluble Receptor Activator for Nuclear Factor κB Ligand (sRANKL) by Whole Blood Cells and Changes in Bone Mineral Density after Estrogen-progestogen Therapy i
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Lee Dong-Ok
Kim Hoon
Chae Soo-Jin
Suh Chang-Suk
Kim Seok-Hyun
Choi Young-Min
Moon Shin-Yong
Kim Jung-Gu
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Abstract
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Objectives: To investigate the relationship between changes in the production of osteoprotegerin (OPG), and soluble receptor activator for nuclear factor κB lignad (sRANKL) by whole blood cells (WBCs) and changes in bone mineral density (BMD) after hormone therapy (HT) in postmenopausal women.
Methods: The production of OPG, and sRANKL by lipopolysaccharide-stimulated WBCs blood cells, serum levels of osteocalcin (OST), type I C-telopeptide breakdown products (Crosslaps; CTX), parathyroid hormone (PTH), calcium, and phosphorus were measured in 224 postmenopausal Korean women. The BMD at lumbar spine and proximal femur was also determined. One hundred and eighteen postmenopausal women took sequential estrogen-progestogen therapy.
Results: The production of OPG by WBCs correlated positively with age and was significantly higher in women with low bone mass than in normal women. The production of sRANKL and sRANKL/OPG correlated negatively with age and was not different according to state of BMD. These OPG and RANKL productions did not show any relationship with serum levels of OST, CTX, PTH, calcium, and phosphorus. After 6 months of HT, the production of OPG by WBCs increased significantly, but no change in the production of sRANKL, and sRANKL/OPG ratio was noted. The 1-year change in BMD of femoral neck correlated negatively with the basal production of OPG by WBCs and positively with basal sRANKL/OPG ratio. Changes in the production of OPG and sRANKL after 6 months of HT were not associated with the 1-year change in BMD.
Conclusion: After HT, changes in the production of OPG, and sRANKL by WBCs did not correlate with changes of BMD, but basal production of OPG by WBCs and sRANKL/OPG ratio correlated with changes in BMD of femoral neck after HT.
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KEYWORD
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Whole blood cells, Osteoprotegerin, sRANKL, Bone mass, Hormone therapy
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